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Polynucleotide Treatment in Pune

Advanced skin regeneration from within — clinically proven PN injections for deep hydration, collagen stimulation, and long-lasting rejuvenation at TDA Clinic.
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Why Are So Many Patients in Pune Choosing PN Skin Booster Treatment in Pune?

As awareness of regenerative aesthetic medicine grows, polynucleotide therapy has rapidly become one of the most requested treatments at TDA Clinic. Patients choose it not because of a trend, but because of what it genuinely offers, a scientifically validated, biologically real improvement in skin health. The most common reasons patients seek PN treatment at TDA include:

  • They want genuine skin repair not a surface fix: Previous treatments have provided temporary improvement or addressed only the surface. PN therapy targets the root cause of skin aging, declining fibroblast activity and collagen depletion, at the dermal level.
  • They have stubborn acne scars or pigmentation: Damage that has not responded fully to peels, creams, or laser treatments often shows meaningful improvement with PN therapy, as collagen remodelling works from within the scar structure.
  • Their skin has lost moisture that topical products cannot restore: Serums and moisturisers hydrate the epidermis. PN therapy restores the skin's intrinsic capacity to retain water within the dermal matrix, a fundamentally different and deeper mechanism.
  • They want a proactive anti-aging approach without injectables like Botox or fillers: PN treatment delivers visible, natural improvement without paralysing muscles or adding external volume, making it the preferred choice for patients who want to age well, not look treated.
They are looking for a safe, clinically backed treatment with minimal downtime: With a short recovery period of 12 to 24 hours and an excellent safety profile, PN therapy fits comfortably into even the busiest lifestyle.

What Is Polynucleotide (PN) Treatment?

Polynucleotide treatment is a clinically proven, non-surgical skin regeneration therapy that uses long-chain DNA molecules, called polynucleotides (PN), derived from sustainably sourced, highly purified salmon DNA. These PN molecules share exceptional biological compatibility with human DNA, making them safe, effective, and well-tolerated across all skin types. When introduced into the skin through micro-injections or microneedling, polynucleotides activate a powerful natural repair process at the cellular level. They bind to specific receptors, called A2A adenosine receptors, on the surface of fibroblast cells in the dermis. This interaction stimulates fibroblasts to produce new collagen, elastin, and hyaluronic acid, the three essential components responsible for skin firmness, elasticity, and hydration.

The result is not a surface-level cosmetic correction, but a genuine biological improvement from within. This leads to a natural, progressive enhancement in skin quality, density, and radiance that topical treatments cannot achieve. Polynucleotide therapy is often compared with PDRN therapy. For clarity, PDRN (polydeoxyribonucleotide) refers to shorter DNA chain fragments, while PN (polynucleotide) involves longer-chain DNA molecules. Both are derived from salmon DNA and work through the same core mechanism of fibroblast stimulation and tissue repair. At TDA Clinic, the most suitable formulation is selected based on individual skin concerns and treatment goals.

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Benefits of Polynucleotide (PN) Skin Booster Treatment

The benefits of polynucleotide treatment are rooted in real biological change. Because the improvement is driven by your own skin’s regenerative process, not an external filler or chemical, results appear natural and sustain over time.

Benefits Include:

  • Intense, Deep Skin Hydration: PN molecules stimulate hyaluronic acid production within the dermis and enhance the skin’s ability to retain moisture, delivering deeper and longer-lasting hydration than topical products.
  • Visible Collagen and Elastin Boost: Fibroblast activation increases collagen and elastin production, helping restore firmness, elasticity, and overall skin strength over time.
  • Smoother Skin Texture and Reduced Scarring: Collagen remodelling improves acne scars, enlarged pores, and uneven texture, resulting in a smoother and more refined skin surface.
  • Brighter, More Even Skin Tone: Improved circulation and skin renewal help reduce dullness and uneven pigmentation, giving the skin a clearer and healthier appearance.
  • Progressive, Natural, Long-Lasting Anti-Aging Results: Results develop gradually over weeks after each session and can last 6 to 12 months with a consistent treatment plan.
Polynucleotide(PN) Treatment

How Does Polynucleotide Treatment Works?

PN therapy works through a precise biological cascade not surface chemistry. Here is a clear, step-by-step explanation of what happens from the moment you arrive at TDA Clinic to the moment your skin begins its regeneration process.

Step 1: Skin Assessment and Protocol Design

Dr. Arshi Rahul carefully assesses your skin and creates a personalised PN protocol based on your concerns, treatment areas, and suitable formulation.

Step 2: Skin Preparation and Numbing

The treatment area is cleansed and a topical numbing cream is applied for 20 to 30 minutes to ensure comfort. Eye protection is used when treating sensitive areas like under the eyes.

Step 3: PN Delivery - The Treatment

The polynucleotide solution is delivered using micro-injections or microneedling, activating fibroblasts to boost collagen and skin repair. The session takes around 20 to 40 minutes.

Step 4: Aftercare & Recovery Guidance

A soothing application is applied to calm the skin, followed by clear aftercare instructions. Mild redness may occur and usually settles within 12 to 24 hours with minimal downtime.

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Who is the ideal candidate for Polynucleotide Treatment?

Suitable for a wide range of skin concerns, PN therapy supports natural skin repair across different age groups and skin types.

A clinically guided, precision-driven PN protocol designed for safe, comfortable, and effective skin regeneration.

Polynucleotide Treatment Procedure at The Daily Aesthetics Clinic, Pune

📝
1

Personalised Consultation & Skin Analysis

Your treatment begins with a detailed clinical consultation by Dr. Arshi Rahul, where your skin is carefully evaluated for hydration, elasticity, texture, pigmentation, and specific concerns. Based on this assessment, a customised PN treatment plan is created, including the right formulation, treatment areas, and session frequency, while also reviewing your medical history and any potential sensitivities.
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2

Patch Test & Treatment Readiness

For first-time patients, a patch test is performed using a small amount of the selected PN solution to ensure complete skin compatibility. Once confirmed, the treatment proceeds in the same session, reinforcing a safety-first approach before full application.
🎯️
3

Skin Preparation & Numbing

The treatment area is thoroughly cleansed using medical-grade products to ensure hygiene and optimal results. A topical numbing cream is then applied and allowed to take full effect, ensuring maximum comfort during the procedure without rushing this critical step.
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4

Precision Polynucleotide Delivery

The PN solution is administered using advanced techniques such as micro-injections or microneedling, depending on your skin needs. This allows the polynucleotides to reach the dermal layer, where they stimulate fibroblasts, boost collagen production, and initiate deep skin repair with controlled, even distribution.
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5

Skin Soothing & Immediate Recovery

After the procedure, a soothing serum or cooling mask is applied to calm the skin, reduce temporary redness, and enhance hydration. This step helps stabilise the skin quickly and improves overall comfort immediately after treatment.

What Conditions Does Polynucleotide Therapy Treat?

Polynucleotide skin booster treatment is a versatile regenerative procedure in aesthetic medicine. Because it works at a fundamental biological level, stimulating the skin’s own repair mechanisms, it helps address multiple skin and scalp concerns linked to declining cellular function and collagen activity.

Full Face

Targets overall skin quality improvement, hydration, tone, texture, fine lines, and early sagging across the entire facial surface.

Under-Eye-Zone

Addresses dark circles, tear trough hollowness, crepey periorbital skin, and fine lines without the risk of filler-related Tyndall effect.

Scalp & Hair

Stimulates dormant follicles, improves scalp microcirculation, and creates the right biological environment for stronger, denser hair growth.

Neck & Jawline

Firms loose neck skin, softens horizontal lines, and restores definition to the jawline, non-surgically and progressively.

Hands

Rejuvenates the thin, aged, and sun-spotted skin on the back of the hands, an often-overlooked area that reveals age clearly.

Décolletage

Repairs sun-damaged, crepey chest skin and restores smoothness and even tone to the décolletage for a more youthful neckline.

Is Polynucleotide Treatment Painful?

Polynucleotide treatment is widely recognised as one of the most comfortable injectable aesthetic procedures available. The needles used for PN delivery are ultra-fine, amongst the smallest gauge used in aesthetic medicine, and the treatment is performed only after thorough application of topical numbing cream. Most patients describe the sensation as mild pressure or a momentary pinching feeling, significantly less uncomfortable than most people anticipate. There is no burning, no significant stinging, and no prolonged discomfort during the session. Each micro-injection takes only a fraction of a second.

Immediately after treatment, the skin may appear slightly pink or flushed, a completely normal response to the micro-injection process. This typically resolves within 12 to 24 hours. There is no visible swelling, no dressings required, and no interruption to your normal activities. Most TDA patients return to work, meetings, or social commitments on the same day. Dr. Rahul and her clinical team monitor your comfort throughout every step of the procedure. Numbing levels and technique are adjusted as needed, and the entire process, from arrival to aftercare application, is designed to be as calm and reassuring as possible.

Polynucleotide vs. Fillers, PRP, Botox and Mesotherapy

Treatment Parameter
PN (Polynucleotide)
HA Fillers
PRP
Botox
Mesotherapy
Type of Therapy
Biological DNA regenerator
Synthetic volume filler
Autologous growth factor
Neuromuscular toxin
Nutrient microinjection
Core Action
Fibroblast activation → collagen
Adds external volume
Platelet growth factors
Relaxes muscles
Nourishes dermis
Treats
Skin quality, hydration, texture
Volume loss, deep lines
Hair, surface repair
Dynamic wrinkles
Dullness, early aging
Natural?
Yes - own biological response
No - external filler added
Yes - own blood used
No - toxin injection
Partial
Downtime
12–24 hours
None to minimal
24–48 hours
None
24–48 hours
Duration
6–12 months
9–18 months
6–9 months
3–6 months
3–6 months
Skin Health Gain
Yes - deep cellular improvement
No - surface volumising
Moderate
No
Mild
Ideal For
Regeneration, hydration, repair
Contouring, lip, folds
Hair, skin repair
Frown lines, crow feet
Glow, early aging

Can Polynucleotide Treatment Be Combined with Other Procedures?

Yes, combining PN therapy with complementary treatments often delivers superior results. At The Daily Aesthetics Clinic, Dr. Arshi Rahul designs personalised protocols to address multiple concerns efficiently, with every combination clinically justified for better outcomes.

1. PN + Microneedling

Why It Works: Microneedling creates micro-channels that allow PN molecules to penetrate significantly deeper into the dermis, amplifying fibroblast activation and accelerating collagen remodelling for faster scar improvement.

2. PN + HydraFacial

Why It Works: HydraFacial deeply cleanses and hydrates the skin surface, while PN works at a cellular level. Together, they deliver instant and lasting skin transformation, effective before a major event.

3. PN + 4D HIFU

Why It Works: HIFU targets the SMAS layer to lift and firm structurally, while PN improves the biological health of the skin above it. The combination addresses both structure and quality, ideal for patients in their 40s and 50s.

4. PN + Chemical Peel

Why It Works: The peel removes the damaged outer layer while PN accelerates regeneration in the dermis below, reducing recovery time, enhancing results, and minimising the risk of post-inflammatory pigmentation.

5. PN + Dermal Fillers

Why It Works: Fillers restore structural volume while PN improves the skin's intrinsic health and quality. This combination provides both immediate lift and progressive biological improvement, creating a natural-looking result.

6. PN + Botox

Why It Works: Botox relaxes expression-driven wrinkles immediately, while PN addresses the underlying skin quality such as collagen, hydration, and texture. Together, they offer a complete anti-aging approach.

How Many Sessions Are Needed for Polynucleotide Treatment?

Most patients require 3 to 4 sessions spaced 3 to 4 weeks apart, followed by maintenance every 4 to 6 months, depending on skin concerns and individual response.

Key factors that influence your session requirement:

  • Severity of concern: Mild issues may improve in 2 to 3 sessions, while advanced aging, scarring, or hair loss usually need 4 sessions.
  • Treatment area: Larger areas like full face, neck, and under-eye may need more sessions than a single zone. Scalp treatment follows a separate protocol.
  • Skin regeneration: Younger or healthier skin responds faster, while collagen-depleted skin may need additional sessions.
  • Lifestyle factors: Sun exposure, stress, smoking, and poor sleep can slow results and increase session requirements.
  • Combination treatments: Pairing PN with microneedling, HydraFacial, or laser can enhance results and may reduce standalone sessions.
  • Consistency of sessions: Timely sessions ensure optimal collagen stimulation and better results.
Polynucleotide (PN) Skin Booster Treatment

Rejuran, Curenex, or Karisma - Which PN Product Is Used at TDA Clinic?

Not all polynucleotide products are the same. At The Daily Aesthetics Clinic, Dr. Arshi Rahul selects the most suitable PN formulation based on your skin type, concern, and sensitivity for optimal results.
Product
Type
Skin Focus
Ideal For
What Sets It Apart
Rejuran [Gold Standard]
PDRN
Anti-aging, skin repair, regeneration
Anti-aging, skin repair, regeneration
The benchmark PDRN treatment — clinically the most validated. Ideal for overall skin quality improvement, deep collagen stimulation, and addressing fine lines. Suitable for most skin types.
Curenex [Hydration Focus]
PDRN+PN
Dehydrated, dull, or fatigued skin
Dehydrated, dull, or fatigued skin
A next-generation formulation combining PDRN and longer-chain PN molecules for superior hydration and radiance. The preferred choice for patients whose primary concern is dullness, dehydration, or lackluster skin.
Karisma [Sensitivity & Repair]
PN (Purified)
Reactive, sensitive, or rosacea-prone skin
Reactive, sensitive, or rosacea-prone skin
A highly purified polynucleotide complex from Italy, formulated specifically for tolerant, gentle delivery. Exceptional for patients with sensitive or compromised skin barriers, post-laser recovery, or first-time PN patients.

Pre-Treatment Care

  • Avoid sun exposure, sunbeds, and self-tanning for at least 2 weeks before treatment to reduce sensitivity.
  • Stop active skincare like retinol, tretinoin, vitamin C, AHAs, and BHAs 3 to 5 days prior.
  • Stay well hydrated and maintain good nutrition to support skin regeneration.
  • Inform your doctor about all medications, supplements, and allergies for safe treatment planning.

Post-Treatment Care

  • Apply the prescribed soothing cream as directed and avoid touching or rubbing the treated area for at least 12 hours.
  • Use SPF 50+ sunscreen daily, as sun exposure can negatively impact and reverse treatment results.
  • Avoid strenuous exercise, saunas, steam, and hot showers for 48 hours to prevent irritation and sensitivity.
  • Pause active skincare ingredients for 5 to 7 days, allowing the skin to heal before resuming retinoids or exfoliating products.

Pre and Post Treatment Care for Polynucleotide Therapy

When Will You See Results? Your Polynucleotide Treatment Timeline

Results develop gradually over weeks as your skin regenerates, delivering progressive and natural improvement after each session.
Timeframe
What's Happening Inside
Visible Changes
Your Experience
Day 1–3 (Post-Treatment)
PN molecules bind to A2A receptors; micro-channels from injections close
Mild pinkness or warmth; subtle plumpness
Minimal downtime; most return to routine same day
Week 1–2
Fibroblast activation underway; early collagen precursors forming
Noticeable glow; skin feels more hydrated and supple
Makeup can resume after 24 hours
Month 1
Active collagen synthesis; dermal density improving at cellular level
Smoother skin texture; fine lines beginning to soften
Patients frequently receive compliments on their glow
Month 2–3
Full extracellular matrix remodelling; elastin fibres strengthening
Significant improvement in firmness, tone, and radiance
Peak visible results — ideal time to document with photos
Month 4–6
Sustained regenerative activity; continued collagen support
Long-lasting evenness, firmness, and skin clarity
Maintenance session recommended to preserve results
6+ Months
Biological regeneration continues if maintenance sessions ongoing
Cumulative improvement in skin age and health markers
Annual protocol maintains results and delays aging signs

Risks and Side Effects of Polynucleotide Treatment

Mild redness and warmth

Mild redness and warmth are the most common effects, usually lasting 12 to 24 hours and resolving without treatment.

Minor localised swelling

Minor localised swelling may occur, especially in sensitive areas like under-eyes or lips, and settles within 24 to 48 hours.

Brief Skin Sensitivity or Tightness

Brief skin sensitivity or tightness may be experienced as part of the natural regeneration process and improves on its own.

Rare Allergic Response

Allergic reactions are very rare due to high biocompatibility, but patients with fish or salmon allergies must inform their doctor.

Minor Swelling at Injection Sites

Small bruises or pinpoint injection marks can appear at injection sites but are temporary and fade within a few days.

Single-session Result Limitation

Polynucleotide treatment works progressively over time, and multiple sessions are required for optimal, long-lasting results.

How Much Does Polynucleotide Treatment Cost in Pune?

At The Daily Aesthetics Clinic, complete pricing transparency is part of the TDA Promise. You will always know exactly what your treatment costs before you commit.

Factors that influence the cost of your treatment:

  • Treatment area and size: Under-eye, full face, neck, or scalp treatments are priced differently based on the area size and zones involved.
  • PN product used: Rejuran, Curenex, or Karisma vary in cost depending on formulation, clinical grade, and country of origin.
  • Number of sessions: The total cost depends on how many sessions are needed based on your concern and its severity level.
  • Combination treatments: Combining PN with microneedling, HydraFacial, peel, or HIFU may adjust pricing and improve overall value.
  • Clinic standards: Use of CE-certified products and advanced protocols ensures quality, safety, and consistency in every session.
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    Find The Daily Aesthetic Clinic Near You

    Kharadi
    Baner
    Kalyani Nagar

    Why Patients Choose TDA Clinic for PN Treatment in Pune?

    At The Daily Aesthetics Clinic, we combine internationally validated science, expert-led care, and a genuinely personalised approach — so your skin receives exactly what it needs, and nothing it does not.

    Expert-led Protocols

    Dr. Arshi Rahul designs and oversees every PN treatment, ensuring safe, medically guided results.

    Certified PN products

    Only CE-certified formulations like Rejuran, Curenex, and Karisma are used for safety and effectiveness.

    Personalised plans

    Each treatment is customised to your skin needs, not based on fixed or standard packages.

    Comfort-Focused Approach

    Advanced numbing and ultra-fine needles ensure minimal discomfort during every session.

    Natural-Looking Results

    Treatments focus on gradual, healthy improvement without overdone or artificial results.

    Complete Aftercare

    Ongoing support, follow-ups, and clear aftercare guidance ensure optimal long-term outcomes.

    Meet Dr. Arshi Rahul

    Aesthetic Professional With A Passion For Beauty

    Dr. Arshi Rahul is a respected aesthetic physician and one of Pune’s leading female skin specialists. With over 10 years of experience in non-surgical aesthetic medicine, she has helped thousands of patients across neighborhoods including Kalyani Nagar, Koregaon Park, Kharadi, Baner, Aundh, Viman Nagar, and Magarpatta achieve healthier, more radiant skin.

    A medical graduate (BHMS, DSA, DNDP) and certified Laser Expert, Dr. Arshi has built her reputation on skill, compassion, and her commitment to staying at the forefront of advanced skin care. She completed her training at the Gold Coast Training Academy in Australia, specializing in skin rejuvenation, injectables, and non-surgical aesthetics.

    Recognized in 2016 as the Best Skincare Expert by City Magazine, Dr. Arshi is known for her artistry with facial aesthetics, precise injector techniques, and her dedication to delivering natural, confident results.

    Driven by a lifelong passion for beauty and wellness, she founded The Daily Aesthetic Skincare to bring modern, evidence-based treatments to Pune in a warm, personalized setting. Whether you’re exploring anti-ageing solutions, laser treatments, or everyday skin care, Dr. Arshi is trusted by patients seeking a female skin specialist who combines expertise with genuine care.

    Meet Dr. Arshi Rahul

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      Frequently Asked Questions (FAQs)

      1. What is Salmon DNA treatment and how does it work?
      Salmon DNA treatment, or PDRN therapy, uses purified polynucleotide fragments derived from salmon DNA. These are injected into the skin, where they stimulate fibroblast cells to produce collagen and repair damaged tissue. The result is healthier, firmer, and more radiant skin over a series of sessions.
      Yes. PDRN therapy is highly safe for all Indian skin tones. Because the treatment stimulates the skin’s own healing process rather than using heat or aggressive chemicals, there is minimal risk of post-inflammatory hyperpigmentation — which is a common concern with laser treatments on darker skin.
      Most patients undergo 3 to 4 sessions, spaced 3 to 4 weeks apart. Initial improvement in skin hydration and glow is often noticeable after the first or second session, while peak results in texture, firmness, and fine lines become visible at the 2 to 3 month mark.
      Both are regenerative treatments, but they work differently. PRP uses growth factors from the patient’s own blood to stimulate healing. Salmon DNA (PDRN) delivers a standardised, consistent dose of polynucleotides that directly activates DNA repair mechanisms. PDRN offers a more predictable and consistent biological response across sessions, as it is not dependent on blood quality.
      Absolutely. Scalp PDRN therapy is a highly effective option for hair restoration. When injected into the scalp, polynucleotides stimulate dormant hair follicles, reduce follicle inflammation, and improve the scalp environment for healthier, denser hair growth. It is suitable for both male and female pattern hair loss.
      Results from a full session protocol typically last 6 to 12 months. A maintenance session every 4 to 6 months is recommended to sustain and build upon the improvement. Patients who follow consistent sun protection and skincare tend to enjoy longer-lasting results.
      Downtime is minimal. Most patients experience mild redness or pinkness for 12 to 24 hours, which is easily concealed with light makeup after 24 hours. There is no swelling, no stitches, and no need for any extended recovery period. Many patients return to their normal day immediately after treatment.
      The terms refer to the same class of treatment. “Salmon sperm facial” is the popular cultural name, while “PDRN therapy” or “Polynucleotide treatment” is the clinical term. The DNA used is extracted, highly purified, and biocompatible — it bears no resemblance to the original biological material in its final clinical form.
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